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Cas cliniques
Synchronous malignant pleural mesothelioma and pulmonary carcinoma in a woman without evidence of asbestos exposure  Envoyer
Abstract: The synchronous development of malignant mesothelioma and pulmonary carcinoma is extremely rare. In this case, an 83-year-old woman, without evidence of past asbestos exposure, developed malignant pleural mesothelioma and pulmonary adenocarcinoma. She was discovered to have a lung lesion on an unrelated preoperative chest X-ray. Clinical evaluation suggested primary bronchogenic malignancy. She had a forty pack-year smoking history, but quit twenty years previously. At surgery, she had nodularity of the pleura. Pathology revealed adenocarcinoma of the lung and suspected malignant mesothelioma of the pleura. Malignant mesothelioma was confirmed histologically at a second surgery. (Source: Respiratory Medicine CME)

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Man Gets Asthma When Logging Into Facebook  Envoyer
A man appeared to have several asthma attacks which five doctors from Italy explain appeared after he had logged into Facebook and gone to a specific page, according to a Correspondence in today's issue of The Lancet. The doctors explain that seeing his girlfriend's details on Facebook seemed to bring on hyperventilation and then asthma. The man, 18, was very sad because his sweetheart had jilted him. She had also erased all details of him from her Facebook, while at the same time developing friendships with young men... (Source: Health News from Medical News Today)
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Two Cases With Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma Successfully Treated With Clarithromycin  Envoyer

A 70-year-old woman with a history of sinobronchial syndrome was admitted to the hospital because of a cough, sputum, and abnormal chest shadow. She was diagnosed with pulmonary mucosa-associated lymphoid tissue lymphoma (p-MALToma) based on results of a pathologic examination and the gene rearrangements in the Ig heavy chain on Southern blot hybridization. Although p-MALToma did not regress with conventional therapy, it was reduced after long-term treatment with clarithromycin (CAM) (200 mg/d). A 57-year-old woman with a history of Sjögren syndrome and lymphocytic interstitial pneumonia had a mass lesion in the left lower lung field. CT image-guided biopsy established a diagnosis of p-MALToma. The p-MALToma regressed with long-term treatment with CAM (200 mg/d), whereas Helicobacter pylori (HP) eradication therapy was not effective in concurrent atrophic gastritis with HP. It is suggested that CAM, a macrolide antibiotic, may be effective in some patients with p-MALToma.

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Transitory, spontaneously recovering, peripheral facial nerve palsy after vionorelbine administration.  Envoyer
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Transitory, spontaneously recovering, peripheral facial nerve palsy after vionorelbine administration.

Tunis Med. 2010 Jul;88(7):513-6

Authors: Cherif J, M'hamdi S, Osman M, Mehiri N, Zouaoui A, Zouheir S, Louzir B, Béji M

BACKGROUND: Vinorelbine is a semi-synthetic vinca alkaloid that has demonstrated a broad spectrum of activity. It is widely used in non small cell lung cancer. CASE REPORT: We report the case of a 50 year old man, having stage IV lung carcinoma with a unique cerebral metastasis in the right hemisphere. Focal cerebral radiotherapy was first administrated followed by intravenous chemotherapy associating vinorelbine to cisplatin. He has developed multiple subsequent and transitory episodes of monolateral peripheral facial nerve palsy in the left side during vinorelbine administration. The palsy has completely and spontaneously resolved at a short interval, around twenty minutes, after the end of the drug infusion. Obvious cerebral tumor progression was excluded by means of CT scan; the drug was thereby administrated as scheduled until the end of the treatment. CONCLUSION: We describe an unusual side effect, until now reported in only two cases, having brain-stem gliomas, among English and French literature, dealing with vinorelbine as adjuvant treatment. We discuss possible neurological and oncological implications.

PMID: 20582890 [PubMed - indexed for MEDLINE]

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Mediastinal teratoma with pulmonary involvement presenting as massive hemoptysis in 2 patients.  Envoyer
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Mediastinal teratoma with pulmonary involvement presenting as massive hemoptysis in 2 patients.

Respir Care. 2010 Aug;55(8):1094-6

Authors: Chen RF, Chang TH, Chang CC, Lee CN

Massive hemoptysis is described in many disease processes. However, a mediastinal teratoma is rarely considered in a patient presenting with massive hemoptysis. Since a mediastinal teratoma has no specific symptoms, its definitive diagnosis is difficult before surgical intervention. Flexible bronchoscopy can be diagnostic in cases of a mediastinal teratoma with involvement of the bronchial tree. We report 2 cases of hemoptysis caused by mediastinal teratoma with bronchial communication.

PMID: 20667158 [PubMed - indexed for MEDLINE]

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