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Cas cliniques
An endobronchial lipoma mimicking asthma and malignancy  Envoyer
Farzan Irani, Bijender Kumar, Prashanth Reddy, Rawan Narwal-Chadha, Rahil Kasmani, James Tita
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[A case of bronchial glomus tumor]  Envoyer
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[A case of bronchial glomus tumor]

Nihon Kokyuki Gakkai Zasshi. 2010 Apr;48(4):303-6

Authors: Inaba M, Ushijima S, Hirata N, Saisyoji T, Kitaoka M, Yoshinaga T

A 67-year-old man was admitted to our hospital because of a cough and hemoptysis. Chest CT and bronchoscopy demonstrated a polypoid tumor in the truncus intermedius. The pathological diagnosis of the biopsy specimens was glomus tumor, which is an extremely rare tumor of the respiratory tract. We performed a successful bronchoscopic removal of the tumor using a high-frequency-wave snare and microwave coagulation. After one year of follow-up, there was no recurrence. To the best of our knowledge, this is only the 24th report of a tracheobronchial glomus tumor.

PMID: 20432972 [PubMed - indexed for MEDLINE]

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Hémoptysie révélatrice d’une amylose trachéobronchique  Envoyer

Article Tunisien Publication year: 2010

Source: Revue de Pneumologie Clinique, In Press, Corrected Proof, Available online 1 April 2010
H., Racil , J., Ben Amar , S.C., Rouhou , G., Laaribi , A., Ayadi , ...

Nous rapportons l’observation d’un homme de 68 ans qui avait consulté pour dyspnée et hémoptysie. La fibroscopie bronchique avait montré une formation bourgeonnante au niveau du versant postérieur de la carène. Des biopsies bronchiques étagées étaient réalisées et avaient conclu à une amylose de type AL.

L’amylose trachéobronchique localisée est une affection très rare, pouvant simuler une tumeur bronchique surtout lorsqu’elle survient chez un sujet de sexe masculin et tabagique.

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Exacerbation of Obstructive Sleep Apnea by Oral Indomethacin  Envoyer

Patients with obstructive sleep apnea (OSA) are predisposed to instability in central ventilatory control during sleep. Increased instability, as reflected in an enhanced expired volume in per unit time loop gain, has been associated with a greater predisposition to upper airway collapse. Here, in an otherwise healthy patient with untreated mild OSA, we describe the further exacerbation of OSA after oral indomethacin administration. The subject was a control subject in part of a study to investigate the effects of altering cerebral blood flow (CBF) on ventilatory responses and sleep. He was administered either placebo or 100 mg of indomethacin orally with 20 mL of antacid 2.5 h before sleep on different days. He was studied overnight by polysomnography, arterial blood gases, and transcranial Doppler ultrasound. Administration of 100 mg of oral indomethacin prior to sleep resulted in an almost doubling of the apnea-hypopnea index (14 to 24/h), compared with placebo. This was due to an increase in apneas, rather than hypopneas. Following the indomethacin, changes in arterial blood gases were unremarkable, but both CBF as indexed using transcranial Doppler ultrasound and CBF reactivity to a steady-state change in CO2 (CBF-CO2) reactivity were reduced, and the ventilatory response to CO2 was elevated. CBF was also further reduced during nonrapid eye movement sleep following the indomethacin when compared with the control night. Indomethacin-induced reductions in CBF and CBF-CO2 reactivity and related increases in ventilatory instability may lead to a greater predisposition to upper airway collapse and related apnea; these factors may partly explain the exacerbation of OSA.

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Guillain-Barré syndrome as a paraneoplastic manifestation of small-cell carcinoma of lung.  Envoyer
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Guillain-Barré syndrome as a paraneoplastic manifestation of small-cell carcinoma of lung.

South Med J. 2010 Feb;103(2):156-8

Authors: Naveed S, Okoli K, Hollingsworth J, Kasmani R

Guillain-Barré syndrome (GBS) encompasses the variants of acute immune-mediated polyneuropathies usually preceded by an infection. A few case reports have associated GBS to neoplastic diseases. It remains unclear whether these are merely coincidental or represent paraneoplastic phenomena. The clinical features of GBS associated with oncological cases do not appear to differ from post-infectious GBS. We report a 74-year-old man in whom small cell carcinoma of lung (SCLC) was diagnosed during a presentation with GBS. Treatment with chemotherapy for SCLC and intravenous immunoglobulins led to complete neurological recovery and tumor regression.

PMID: 20175250 [PubMed - indexed for MEDLINE]

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