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L'essentiel de la littérature réçente en Pneumologie

Dans cette rubrique on vous propose une revue de la littérature à travers une sélection d'abstracts d'articles originaux.
On essaiera de vous tenir informé des dernières nouveautés de recherche en matière de Pneumologie. On ne vous fournit que le résumé de l'article et le lien correspondant, pour accéder à l'article en full text vous devez être inscrits à la revue correspondante.
Cliquez ici pour consulter la liste des revues de Pneumologie disponibles en libre accès.



Insights from human genetic studies of lung and organ fibrosis. Imprimer Envoyer
Vendredi, 05 Janvier 2018 08:05
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Insights from human genetic studies of lung and organ fibrosis.

J Clin Invest. 2018 Jan 02;128(1):36-44

Authors: Garcia CK

Abstract
Genetic investigations of fibrotic diseases, including those of late onset, often yield unanticipated insights into disease pathogenesis. This Review focuses on pathways underlying lung fibrosis that are generalizable to other organs. Herein, we discuss genetic variants subdivided into those that shorten telomeres, activate the DNA damage response, change resident protein expression or function, or affect organelle activity. Genetic studies provide a window into the downstream cascade of maladaptive responses and pathways that lead to tissue fibrosis. In addition, these studies reveal interactions between genetic variants, environmental factors, and age that influence the phenotypic spectrum of disease. The discovery of forces counterbalancing inherited risk alleles identifies potential therapeutic targets, thus providing hope for future prevention or reversal of fibrosis.

PMID: 29293091 [PubMed - in process]

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Developmental mechanisms and adult stem cells for therapeutic lung regeneration. Imprimer Envoyer
Vendredi, 05 Janvier 2018 08:05
Related Articles

Developmental mechanisms and adult stem cells for therapeutic lung regeneration.

Dev Biol. 2018 Jan 15;433(2):166-176

Authors: Lee JH, Rawlins EL

Abstract
Chronic degenerative lung diseases are essentially untreatable pathological conditions. By contrast, the healthy lung has numerous mechanisms that allow for rapid repair and restoration of function following minor acute injuries. We discuss the normal endogenous processes of lung development, homeostatic maintenance and repair and consider the research strategies required for the development of methods for human therapeutic lung regeneration.

PMID: 29291971 [PubMed - in process]

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Radiomics and radiogenomics in lung cancer: A review for the clinician. Imprimer Envoyer
Vendredi, 05 Janvier 2018 08:05
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Radiomics and radiogenomics in lung cancer: A review for the clinician.

Lung Cancer. 2018 Jan;115:34-41

Authors: Thawani R, McLane M, Beig N, Ghose S, Prasanna P, Velcheti V, Madabhushi A

Abstract
Lung cancer is responsible for a large proportion of cancer-related deaths across the globe, with delayed detection being perhaps the most significant factor for its high mortality rate. Though the National Lung Screening Trial argues for screening of certain at-risk populations, the practical implementation of these screening efforts has not yet been successful and remains in high demand. Radiomics refers to the computerized extraction of data from radiologic images, and provides unique potential for making lung cancer screening more rapid and accurate using machine learning algorithms. The quantitative features analyzed express subvisual characteristics of images which correlate with pathogenesis of diseases. These features are broadly classified into four categories: intensity, structure, texture/gradient, and wavelet, based on the types of image attributes they capture. Many studies have been done to show correlation between these features and the malignant potential of a nodule on a chest CT. In cancer patients, these nodules also have features that can be correlated with prognosis and mutation status. The major limitations of radiomics are the lack of standardization of acquisition parameters, inconsistent radiomic methods, and lack of reproducibility. Researchers are working on overcoming these limitations, which would make radiomics more acceptable in the medical community.

PMID: 29290259 [PubMed - in process]

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