payday loans
wholesale jerseys
Skip to content

Accueil Out of proportion pulmonary hypertension in obstructive lung diseases
Out of proportion pulmonary hypertension in obstructive lung diseases Imprimer Envoyer
Mercredi, 07 Février 2018 07:16

imagePurpose of review Pulmonary hypertension is common (25–90%) in chronic obstructive pulmonary diseases (COPDs). Severe pulmonary hypertension, however, is quite rare (1–3%). The term ‘out of proportion’ pulmonary hypertension is still widely used. New guidelines instead propose to use the term ‘Severe pulmonary hypertension’ if mean pulmonary arterial pressure at least 35 mmHg or cardiac index (CI) is less than 2.0 l/min/m2 on right heart catheterization (RHC). Why only a minority of COPD patients develop severe pulmonary hypertension is unclear.

Recent findings When present, severe pulmonary hypertension in COPD is associated with increased dyspnea and decreased survival and often does not closely correlate with degree of obstructive abnormality on pulmonary function testing. COPD patients with severe pulmonary hypertension experience circulatory limitation at maximum exercise, and not ventilatory limitation, which is typical for moderate-to-severe COPD patients with no or moderate pulmonary hypertension.

Summary There is no conclusive evidence to support or completely reject the possibility of the use of specific pulmonary arterial hypertension (PAH) therapies in pulmonary hypertension associated with COPD. In mild-to-moderate COPD patients who have severe and progressive symptoms, and have evidence of severe pulmonary hypertension on RHC, specific PAH therapies may be used similar to WHO group-I PAH guidelines.

Read Full Article




World Allergy Week 2017 The Agony of Hives


PubMed Logo


Langtolang Dictionary



Notre site est optimisé pour les Navigateurs suivants : Firefox, Safari et Google Chrome. Cliquez sur l'un des logos ci-dessus pour le télécharger et l'installer gratuitement.


Accueil Out of proportion pulmonary hypertension in obstructive lung diseases Top