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Accueil Mesenchymal Stem Cells in Fibrotic Disease.
Mesenchymal Stem Cells in Fibrotic Disease. Imprimer Envoyer
Dimanche, 06 Août 2017 17:57
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Mesenchymal Stem Cells in Fibrotic Disease.

Cell Stem Cell. 2017 Aug 03;21(2):166-177

Authors: El Agha E, Kramann R, Schneider RK, Li X, Seeger W, Humphreys BD, Bellusci S

Abstract
Fibrosis is associated with organ failure and high mortality and is commonly characterized by aberrant myofibroblast accumulation. Investigating the cellular origin of myofibroblasts in various diseases is thus a promising strategy for developing targeted anti-fibrotic treatments. Recent studies using genetic lineage tracing technology have implicated diverse organ-resident perivascular mesenchymal stem cell (MSC)-like cells and bone marrow-MSCs in myofibroblast generation during fibrosis development. In this Review, we give an overview of the emerging role of MSCs and MSC-like cells in myofibroblast-mediated fibrotic disease in the kidney, lung, heart, liver, skin, and bone marrow.

PMID: 28777943 [PubMed - in process]


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